113th Annual Meeting of the Japanese Society of Pathology held in Nagoya

Isao Shimokawa, Toshimitsu Komatsu, and colleagues presented their research results at the 113th Annual Meeting of the Japanese Society of Pathology held in Nagoya, Japan, on March 30, 2024: Hepatic FoxO3 regulates whole-body energy metabolism and insulin resistance during aging. Proceedings of The Japanese Society of Pathology: 113 (1), 334. This is one of the projects that Komatsu, Shimokawa, et al. are conducting in the Department of Pathology, Nagasaki University School of Medicine, Graduate School of Biomedical Sciences, to study the regulation of aging, showing that hepatocyte-specific deficiency of FoxO3 causes aging-related obesity, hyperglycemia, and insulin resistance in mice. This suggests that hepatocyte FoxO3 is a target for the prevention and treatment of age-related insulin resistance, diabetes, and related diseases.